Bone regeneration using stem cells
Numerous studies have investigated the regenerative effect of transplanted rodent, rabbit and human ADSCs on bone regeneration in a variety of defect systems. These positive effects of ADSCs were also reported in a case study using a combination of autologous ADSCs and iliac crest cells to reconstruct a severe head injury. While chronic infection after reconstructive surgery resulted in an unstable skull with obvious bone defects, new bone formation and almost complete continuity were observed three months after stem cell injection.
We see the use of ADSCs / stem cells among other things in the therapy of femoral head necrosis or deep bone defects: For example, avascular necrosis of the femoral head leads to massive pain and in its final stage to osteoarthritis and the need for total hip replacement. In these avascular necrosis of the femoral head, the cells are inserted into the femoral head via small holes drilled from the outside with intact cartilage in order to develop their effect there. Two months after the “operation”, the ADSCs increased osteogenesis and the microstructure of the vasodraint-induced osteonecrotic tissue.
However, bone healing can also be carried out by the injection of ADSCs in the case of deep-reaching bone defects / edemas or necrosis and, based on this, secondary cartilage healing can take place.